Limb pain may have different types of origin from entrapment of spinal nerves, peripheral nerves, inflammation of blood vessels, damage of peripheral nerves, post-surgical pain, to metabolic complications from underlying diseases. All undiagnosed intractable limb pain should be evaluated by interventional pain physicians experienced in anesthetizing the anatomical sympathetic nerves to limbs. Only when patients are unable to tolerate anti-seizure medications, antidepressants, anti-inflammatory or opiates should they be considered for spinal cord stimulator/neuromodulation treatments.